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In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors

30 Jan 2020

Abstract excerpt

Sleeping sickness is a fatal disease caused by the protozoan parasite Trypanosoma brucei (Tb). Inosine-5'-monophosphate dehydrogenase (IMPDH) has been proposed as a potential drug target, since it maintains the balance between guanylate deoxynucleotide and ribonucleotide levels that is pivotal for the parasite. Here we report the structure of TbIMPDH at room temperature utilizing free-electron laser radiation on...

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PMID: 32001697
DOI: 10.1038/s41467-020-14484-w

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