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Reducing Donor-specific Antibody During Acute Rejection Diminishes Long-term Renal Allograft Loss: Comparison of Early and Late Rejection.

Transplantation - 1 Nov 2020

Lichvar Alicia B, Tremblay Simon, Leino Abbie D, Shields Adele R, Cardi Michael A, Abu Jawdeh Bassam G, Govil Amit, Kremer Joseph, Cuffy Madison, Paterno Flavio, Diwan Tayyab, Brailey Paul, Girnita Alin, Alloway Rita R, Woodle E Steve

Abstract excerpt

BACKGROUND: Reduction in donor-specific antibody (DSA) has been associated with improved renal allograft survival after antibody-mediated rejection (AMR). These observations have not been separately analyzed for early and late AMR and mixed acute rejection (MAR). The purpose of this study was to evaluate long-term responses to proteasome inhibitor-based therapy for 4 rejection phenotypes and to determine factors...

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PMID: 32000256
DOI: 10.1097/TP.0000000000003145

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