Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency.

doi:10.1056/NEJMoa1910640

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Article

Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency.

The New England journal of medicine - 30 Jan 2020

Drutman Scott B, Mansouri Davood, Mahdaviani Seyed Alireza, Neehus Anna-Lena, Hum David, Bryk Ruslana, Hernandez Nicholas, Belkaya Serkan, Rapaport Franck, Bigio Benedetta, Fisch Robert, Rahman Mahbuba, Khan Taushif, Al Ali Fatima, Marjani Majid, Mansouri Nahal, Lorenzo-Diaz Lazaro, Emile Jean-François, Marr Nico, Jouanguy Emmanuelle, Bustamante Jacinta, Abel Laurent, Boisson-Dupuis Stéphanie, Béziat Vivien, Nathan Carl, Casanova Jean-Laurent

Abstract excerpt

BACKGROUND: Cytomegalovirus (CMV) can cause severe disease in children and adults with a variety of inherited or acquired T-cell immunodeficiencies, who are prone to multiple infections. It can also rarely cause disease in otherwise healthy persons. The pathogenesis of idiopathic CMV disease is unknown. Inbred mice that lack the gene encoding nitric oxide synthase 2 (Nos2) are susceptible to the related murine...

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PMID: 31995689
DOI: 10.1056/NEJMoa1910640
PMCID: PMC7063989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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