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Article

Construction of a Neuro-Immune-Cognitive Pathway-Phenotype Underpinning the Phenome of Deficit Schizophrenia.

Current topics in medicinal chemistry - 1 Jan 2020

Al-Hakeim Hussein K, Almulla Abbas F, Al-Dujaili Arafat H, Maes Michael

Abstract excerpt

BACKGROUND: In schizophrenia, pathway-genotypes may be constructed by combining interrelated immune biomarkers with changes in specific neurocognitive functions that represent aberrations in brain neuronal circuits. These constructs provide an insight on the phenome of schizophrenia and show how pathway-phenotypes mediate the effects of genome X environmentome interactions on the symptomatology/phenomenology of...

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PMID: 31994463
DOI: 10.2174/1568026620666200128143948

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