Article
celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.
eLife - 27 Jan 2020
Li Chunmei, Barton Carrie, Henke Katrin, Daane Jake, Treaster Stephen, Caetano-Lopes Joana, Tanguay Robyn L, Harris Matthew P
Abstract excerpt
The use of genetics has been invaluable in defining the complex mechanisms of aging and longevity. Zebrafish, while a prominent model for vertebrate development, have not been used systematically to address questions of how and why we age. In a mutagenesis screen focusing on late developmental phenotypes, we identified a new mutant that displays aging phenotypes at young adult stages. We find that the phenotypes...
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