Article
Stratified meta-analysis by ethnicity revealed that ADRB3 Trp64Arg polymorphism was associated with coronary artery disease in Asians, but not in Caucasians.
Medicine - 1 Jan 2020
Chen Yingjian, Liao Yuanjun, Sun Shengnan, Lin Fan, Li Rang, Lan Shujin, Zhao Xiaolei, Qin Jiheng, Rao Shaoqi
Abstract excerpt
BACKGROUND: Previous studies demonstrated that ADRB3, beta-3 adrenergic receptor, participated in lipolysis and thermogenesis in adipose tissue. Consequently, this gene has attracted an increasing number of genetic studies examining its association with coronary artery disease (CAD) in different ethnicities in recent years, but no conclusion has been reached so far. The aim of this study was to explore whether...
Topics
- Asian People
- Case-Control Studies
- Coronary Artery Disease
- Genetic Predisposition to Disease
- Humans
- Polymorphism, Single Nucleotide
- Receptors, Adrenergic, beta-3
- White People