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New selective thiolate gold( i ) complexes inhibit the proliferation of different human cancer cells and induce apoptosis in primary cultures of mouse colon tumors

1 Jan 2020

Abstract excerpt

New thiolate gold(i) complexes with P(NMe2)3 (HMPT) as a phosphane group [Au(SR)(HMPT)] (SR = Spy, Spyrim, SMe2pyrim, Sbenzothiazole, Sthiazoline, Sbenzimidazole and 2-thiouracil) have been synthesized. All of them have been characterized, including X-ray studies of complexes with SMe2pyrim, Sbenzothiazole and 2-thiouracil moieties. In addition, their potential application as anticancer drugs has been analyzed by...

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PMID: 31971194
DOI: 10.1039/c9dt04423j

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