Article
Multiallelic rare variants support an oligogenic origin of sudden cardiac death in the young.
Herz - 1 Apr 2021
Jaouadi Hager, Bouyacoub Yosra, Chabrak Sonia, Kraoua Lilia, Zaroui Amira, Elouej Sahar, Nagara Majdi, Dallali Hamza, Delague Valérie, Levy Nicolas, Benkhalifa Rym, Mechmeche Rachid, Zaffran Stéphane, Abdelhak Sonia
Abstract excerpt
Unexplained sudden death in the young is cardiovascular in most cases. Structural and conduction defects in cardiac-related genes can conspire to underlie sudden cardiac death. Here we report a clinical investigation and an extensive genetic assessment of a Tunisian family with sudden cardiac death in young members. In order to identify the family-genetic basis of sudden cardiac death, we performed Whole Exome...
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