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Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation

22 Jan 2020

Abstract excerpt

Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in growth during gestation are related to altered placental function. Placental function is regulated by epigenetic mechanisms such as DNA methylation. Several studies in recent years have demonstrated associations between altered...

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PMID: 31969597
DOI: 10.1038/s41598-020-57725-0

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