Article
Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers.
Journal of affective disorders - 15 Feb 2020
Daniels Stephen, Horman Thomas, Lapointe Thomas, Melanson Brett, Storace Alexandra, Kennedy Sidney H, Frey Benicio N, Rizvi Sakina J, Hassel Stefanie, Mueller Daniel J, Parikh Sagar V, Lam Raymond W, Blier Pierre, Farzan Faranak, Giacobbe Peter, Milev Roumen, Placenza Franca, Soares Claudio N, Turecki Gustavo, Uher Rudolf, Leri Francesco
Abstract excerpt
BACKGROUND: Reverse translating putative biomarkers of depression from patients to animals is complex because Major Depressive Disorder (MDD) is a highly heterogenous condition. This review proposes an approach to reverse translation based on relating relevant bio-behavioural functions in laboratory rodents to MDD symptoms. METHODS: This systematic review outlines symptom clusters assessed by psychometric tests...
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