Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development and Characterisation of a Human Chronic Skin Wound Cell Line-Towards an Alternative for Animal Experimentation.

International journal of molecular sciences - 27 Mar 2018

Caley Matthew, Wall Ivan B, Peake Matthew, Kipling David, Giles Peter, Thomas David W, Stephens Phil

Abstract excerpt

Background: Chronic skin wounds are a growing financial burden for healthcare providers, causing discomfort/immobility to patients. Whilst animal chronic wound models have been developed to allow for mechanistic studies and to develop/test potential therapies, such systems are not good representations of the human chronic wound state. As an alternative, human chronic wound fibroblasts (CWFs) have permitted an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Chronic Disease

Share to Fibroblasts

Share to Skin Diseases

Share to Telomerase

Share to Wound Healing

Source

Open in PubMed Open full text

Identifiers

PMID: 29584680
DOI: 10.3390/ijms19041001
PMCID: PMC5979489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development and Characterisation of a Human Chronic Skin Wound Cell Line-Towards an Alternative for Animal Experimentation.PMID 29584680Read ↗

Modeling Wound Chronicity In Vivo: The Translational Challenge to Capture the Complexity of Chronic WoundsSemantic proximity Read ↗

Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing WoundsSemantic proximity Read ↗

An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype.Semantic proximity Read ↗

Strategies to make human skin models based on cellular senescence for ageing researchSemantic proximity Read ↗

[Chronic wounds. Novel approaches in research and therapy].Semantic proximity Read ↗

Development and validation of novel keloid-derived immortalized fibroblast cell linesSemantic proximity Read ↗

Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal modelsSemantic proximity Read ↗

Modeling of the Senescence-Associated Phenotype in Human Skin Fibroblasts.Semantic proximity Read ↗

Myofibroblast progeny in wound biology and wound healing studiesSemantic proximity Read ↗

Maintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditionsSemantic proximity Read ↗

Diminished and altered cellular senescence response in delayed wound healing of agingSemantic proximity Read ↗

Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.