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Article

Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53.

Journal of molecular and cellular cardiology - 1 Feb 2020

Haywood Mary E, Cocciolo Andrea, Porter Kadijah F, Dobrinskikh Evgenia, Slavov Dobromir, Graw Sharon L, Reece T Brett, Ambardekar Amrut V, Bristow Michael R, Mestroni Luisa, Taylor Matthew R G

Abstract excerpt

AIMS: One-third of DCM patients experience ventricular tachycardia (VT), but a clear biological basis for this has not been established. The purpose of this study was to identify transcriptome signatures and enriched pathways in the hearts of dilated cardiomyopathy (DCM) patients with VT. METHODS AND RESULTS: We used RNA-sequencing in explanted heart tissue from 49 samples: 19 DCM patients with VT, 16 DCM...

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Share to Arrhythmias, Cardiac
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31958463
DOI: 10.1016/j.yjmcc.2019.12.010
PMCID: PMC7144813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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