Article
MicroRNA-149 suppresses the malignant phenotypes of ovarian cancer via downregulation of MSI2 and inhibition of PI3K/AKT pathway.
European review for medical and pharmacological sciences - 1 Jan 2020
Zhao L-W, Yu A-J, Zhang Y-J, Wang X-C, Han B, Wang X-H
Abstract excerpt
OBJECTIVE: Ovarian cancer (OC) is one of the most lethal gynecologic malignant tumors. Emerging evidence has indicated that the dysregulation of microRNAs (miRNAs/miRs) participates in the OC progression. It has been revealed that miR-149 acts either as an oncogene or a tumour suppressor in various human tumors. The current study focused on the biological roles and potential mechanism of miR-149 in OC. PATIENTS...
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