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Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine

16 Jan 2020

Abstract excerpt

Abstract The CD2-like African swine fever virus (ASFV) gene 8DR, (also known as EP402R) encodes for a structural transmembrane glycoprotein that has been shown to mediate hemadsorption and be involved in host immunomodulation as well as the induction of protective immune response. In addition, several natural ASFV isolates showing decreased virulence in swine has been shown to be non-hemadsorbing suggesting an...

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PMID: 31949276
DOI: 10.1038/s41598-020-57455-3

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Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swinePMID 31949276Read ↗

A protective multiple gene-deleted African swine fever virus genotype II, Georgia 2007/1, expressing a modified non-haemadsorbing CD2v protein.Semantic proximity Read ↗

Deletion of the K145R and DP148R Genes from the Virulent ASFV Georgia 2007/1 Isolate Delays the Onset, but Does Not Reduce Severity, of Clinical Signs in Infected PigsSemantic proximity Read ↗

Deletion of the African Swine Fever Virus Gene DP148R Does Not Reduce Virus Replication in Culture but Reduces Virus Virulence in Pigs and Induces High Levels of Protection against ChallengeSemantic proximity Read ↗

Deletion of African Swine Fever Virus Histone-like Protein, A104R from the Georgia Isolate Drastically Reduces Virus Virulence in Domestic PigsSemantic proximity Read ↗

Differential Effect of the Deletion of African Swine Fever Virus Virulence-Associated Genes in the Induction of Attenuation of the Highly Virulent Georgia StrainSemantic proximity Read ↗

Deletion of the EP402R Gene from the Genome of African Swine Fever Vaccine Strain ASFV-G-∆I177L Provides the Potential Capability of Differentiating between Infected and Vaccinated AnimalsSemantic proximity Read ↗

The C962R ORF of African Swine Fever Strain Georgia Is Non-Essential and Not Required for Virulence in SwineSemantic proximity Read ↗

Simultaneous Deletion of the9GLandUKGenes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous ChallengeSemantic proximity Read ↗

Deletion of the CD2v Gene from the Genome of ASFV-Kenya-IX-1033 Partially Reduces Virulence and Induces Protection in PigsSemantic proximity Read ↗

Differential Effect of Deleting Members of African Swine Fever Virus Multigene Families 360 and 505 from the Genotype II Georgia 2007/1 Isolate on Virus Replication, Virulence, and Induction of Protection.Semantic proximity Read ↗

Deletion of the H240R Gene in African Swine Fever Virus Partially Reduces Virus Virulence in SwineSemantic proximity Read ↗

African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus challengeSemantic proximity Read ↗

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