Article
Evolution of Mycobacterium tuberculosis complex lineages and their role in an emerging threat of multidrug resistant tuberculosis in Bamako, Mali.
Scientific reports - 15 Jan 2020
Senghore Madikay, Diarra Bassirou, Gehre Florian, Otu Jacob, Worwui Archibald, Muhammad Abdul Khalie, Kwambana-Adams Brenda, Kay Gemma L, Sanogo Moumine, Baya Bocar, Orsega Susan, Doumbia Seydou, Diallo Souleymane, de Jong Bouke C, Pallen Mark J, Antonio Martin
Abstract excerpt
In recent years Bamako has been faced with an emerging threat from multidrug resistant TB (MDR-TB). Whole genome sequence analysis was performed on a subset of 76 isolates from a total of 208 isolates recovered from tuberculosis patients in Bamako, Mali between 2006 and 2012. Among the 76 patients, 61(80.3%) new cases and 15(19.7%) retreatment cases, 12 (16%) were infected by MDR-TB. The dominant lineage was the...
Topics
- Adolescent
- Adult
- Cameroon
- Child
- Child, Preschool
- Female
- Genotype
- Ghana
- Humans
- Infant