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A Factor I-Like Activity Associated with Chikungunya Virus Contributes to Its Resistance to the Human Complement System

13 Jan 2020

Abstract excerpt

Chikungunya virus is a vector-borne pathogen of global significance. The morbidity associated with chikungunya virus (CHIKV) infection, neurovirulence and adaptability to Aedes albopictus , necessitates a deeper understanding of the interaction of CHIKV with the host immune system. Here, we demonstrate that CHIKV is resistant to neutralization by one of the potent barriers of the innate immune arm, the complement...

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PMID: 31941783
DOI: 10.1128/jvi.02062-19

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