Article
Evaluation of dsDNA from extracellular vesicles (EVs) in pediatric AML diagnostics.
Annals of hematology - 1 Mar 2020
Kontopoulou Evangelia, Strachan Sarah, Reinhardt Katarina, Kunz Fabienne, Walter Christiane, Walkenfort Bernd, Jastrow Holger, Hasenberg Mike, Giebel Bernd, von Neuhoff Nils, Reinhardt Dirk, Thakur Basant Kumar
Abstract excerpt
Acute myeloid leukemia (AML) is a heterogeneous malignant disease characterized by a collection of genetic and epigenetic changes. As a consequence, AML can evolve towards more aggressive subtypes during treatment, which require additional therapies to prevent future relapse. As we have previously detected double-stranded DNA (dsDNA) in tumor-derived extracellular vesicles (EVs), in this current study we...
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