Article
Comparison Between Three Molecular Diagnostics for the Identification of Heterozygous Hemoglobin E.
Pakistan journal of biological sciences : PJBS - 1 Jan 2020
Arif Ahmad Al, An-Nizamiya Atina Darajaat, Putri Chintya, Nashrurrokhman Muh, Husna Nailil, Mulyati, Hadisusanto Suwarno, Handayani Niken Satuti Nur
Abstract excerpt
BACKGROUND AND OBJECTIVES: Hemoglobin E is a variant hemoglobin caused due to the base substitution G→A at codon 26 in the β-globin-coding gene that is followed by the alteration of glutamic acid (GAG) to lysine (AAG). Various types of molecular analysis methods such as tetra-primer amplification refractory mutation system (T-ARMS-PCR), Tm-shift real-time polymerase chain reaction (Tm-shift qPCR) and...
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