Article
A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease.
Clinical and translational gastroenterology - 1 Jan 2020
Abshagen Kerstin, Berger Claudia, Dietrich Arne, Schütz Tatjana, Wittekind Christian, Stumvoll Michael, Blüher Matthias, Klöting Nora
Abstract excerpt
OBJECTIVES: We tested the hypothesis that a genetic deletion (Del) variant in the REPIN1 gene is associated with the severity of nonalcoholic fatty liver disease (NAFLD) in humans. METHODS: Sixty-three donors of liver biopsies from individuals with obesity and different degrees of NAFLD and fibrosis were screened for a Del REPIN1 gene variant and liver REPIN1 mRNA expression. RESULTS: In 8 homozygous Del...
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