Article
Assisted reproduction mediated resurrection of a feline model for Chediak-Higashi syndrome caused by a large duplication in LYST.
Scientific reports - 9 Jan 2020
Buckley R M, Grahn R A, Gandolfi B, Herrick J R, Kittleson M D, Bateman H L, Newsom J, Swanson W F, Prieur D J, Lyons L A
Abstract excerpt
Chediak-Higashi Syndrome (CHS) is a well-characterized, autosomal recessively inherited lysosomal disease caused by mutations in lysosomal trafficking regulator (LYST). The feline model for CHS was originally maintained for ~20 years. However, the colonies were disbanded and the CHS cat model was lost to the research community before the causative mutation was identified. To resurrect the cat model, semen was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.