Article
The role of genetics in pulmonary arterial hypertension.
The Journal of pathology - 1 Jan 2017
Ma Lijiang, Chung Wendy K
Abstract excerpt
Group 1 pulmonary hypertension or pulmonary arterial hypertension (PAH) is a rare disease characterized by proliferation and occlusion of small pulmonary arterioles, leading to progressive elevation of pulmonary artery pressure and pulmonary vascular resistance, and right ventricular failure. Historically, it has been associated with a high mortality rate, although, over the last decade, treatment has improved...
Topics
- Bone Morphogenetic Protein Receptors, Type II
- Genetic Predisposition to Disease
- Heart Defects, Congenital
- Humans
- Hypertension, Pulmonary
- Mutation
- Vascular Resistance