Article
Mitophagy contributes to endothelial adaptation to simulated microgravity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2020
Locatelli Laura, Cazzaniga Alessandra, De Palma Clara, Castiglioni Sara, Maier Jeanette A M
Abstract excerpt
Exposure to real or simulated microgravity is sensed as a stress by mammalian cells, which activate a complex adaptive response. In human primary endothelial cells, we have recently shown the sequential intervention of various stress proteins which are crucial to prevent apoptosis and maintain cell function. We here demonstrate that mitophagy contributes to endothelial adaptation to gravitational unloading. After...
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