Article
MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure.
EBioMedicine - 1 Jan 2020
Pereira Ana Helena M, Cardoso Alisson C, Consonni Silvio R, Oliveira Renata R, Saito Angela, Vaggione Maria Luisa B, Matos-Souza Jose R, Carazzolle Marcelo F, Gonçalves Anderson, Fernandes Juliano L, Ribeiro Gustavo C A, Lopes Mauricio M, Molkentin Jeffery D, Franchini Kleber G
Abstract excerpt
BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but the underlying mechanisms remain elusive. Alternative splicing of MEF2C exons α, β and γ provides transcript diversity with gene activation or repression functionalities. METHODS: Neonatal and adult rat ventricular myocytes were used to overexpress MEF2C splicing variants γ+ (repressor) or...
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