Article
Heterogeneity of Treg/Th17 According to Cancer Progression and Modification in Biliary Tract Cancers via Self-Producing Cytokines.
Digestive diseases and sciences - 1 Oct 2020
Kinoshita Mitsuru, Kobayashi Shogo, Gotoh Kunihito, Kubo Masahiko, Hayashi Koji, Iwagami Yoshifumi, Yamada Daisaku, Akita Hirofumi, Noda Takehiro, Asaoka Tadafumi, Takeda Yutaka, Tanemura Masahiro, Eguchi Hidetoshi, Urakawa Shinya, Goto Kumiko, Maekawa Kayoko, Wada Hisashi, Mori Masaki, Doki Yuichiro
Abstract excerpt
BACKGROUND/AIM: We previously demonstrated that inflammatory cytokine interleukin-6 (IL-6) was produced during cancer progression, worked together with transforming growth factor-beta 1 (TGF-β1), and induced the epithelial-mesenchymal transition (EMT) with chemo-resistance against gemcitabine (GR) at the invasion front of biliary tract cancers (BTCs). However, the significance of cytokine-induced T cell...
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