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Article

53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy

2 Dec 2019

Abstract excerpt

Multifractionated irradiation is the mainstay of radiation treatment in cancer therapy. Yet, little is known about the cellular DNA repair processes that take place between radiation fractions, even though understanding the molecular mechanisms promoting cancer cell recovery and survival could improve patient outcome and identify new avenues for targeted intervention. To address this knowledge gap, we...

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PMID: 31822909
DOI: 10.1093/nar/gkz1139

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