Evaluation of BRAF, RAS, RET/PTC, and PAX8/PPARg alterations in different Bethesda diagnostic categories: A multicentric prospective study on the validity of the 7-gene panel test in 1172 thyroid FNAs deriving from different hospitals in South Italy.

doi:10.1002/cncy.22217

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Evaluation of BRAF, RAS, RET/PTC, and PAX8/PPARg alterations in different Bethesda diagnostic categories: A multicentric prospective study on the validity of the 7-gene panel test in 1172 thyroid FNAs deriving from different hospitals in South Italy.

Cancer cytopathology - 1 Feb 2020

Bellevicine Claudio, Migliatico Ilaria, Sgariglia Roberta, Nacchio Mariantonia, Vigliar Elena, Pisapia Pasquale, Iaccarino Antonino, Bruzzese Dario, Fonderico Francesco, Salvatore Domenico, Biondi Bernadette, Masone Stefania, Novizio Vincenzo, Scavuzzo Francesco, Serino Domenico, De Palma Maurizio, Chiofalo Maria Grazia, Botti Gerardo, Pezzullo Luciano, Nuzzo Vincenzo, Spiezia Stefano, De Chiara Giovanni, Iorio Sergio, Conzo Giovanni, Docimo Giovanni, Faggiano Antongiulio, Bongiovanni Massimo, Malapelle Umberto, Colao Annamaria, Triassi Maria, Troncone Giancarlo

Abstract excerpt

BACKGROUND: Thyroid fine-needle aspiration (FNA) is a reliable and cost-effective diagnostic tool for establishing the nature of thyroid nodules, although up to 30% of FNAs are still classified as "indeterminate." Molecular testing of FNAs could improve preoperative diagnosis, thereby reducing unnecessary surgery. In this multicenter prospective study the authors investigated, using a 7-gene assay, the...

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PMID: 31821746
DOI: 10.1002/cncy.22217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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