Article
Origin of Lactose Fermentation in Kluyveromyces lactis by Interspecies Transfer of a Neo-functionalized Gene Cluster during Domestication.
Current biology : CB - 16 Dec 2019
Varela Javier A, Puricelli Martina, Ortiz-Merino Raúl A, Giacomobono Romina, Braun-Galleani Stephanie, Wolfe Kenneth H, Morrissey John P
Abstract excerpt
Humans have used yeasts to make cheese and kefir for millennia, but the ability to ferment the milk sugar lactose is found in only a few yeast species, of which the foremost is Kluyveromyces lactis [1]. Two genes, LAC12 (lactose permease) and LAC4 (lactase), are sufficient for lactose uptake and hydrolysis to glucose and galactose [2]. Here, we show that these genes have a complex evolutionary history in the...
Topics
- Cellobiose
- Domestication
- Evolution, Molecular
- Fermentation
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genome, Fungal
- Genotype
- Kluyveromyces
- Lactose
- Multigene Family
- Phenotype
- Phylogeny