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Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics

2 Dec 2019

Abstract excerpt

The current treatment regimen for lymphatic filariasis is mostly microfilaricidal. In an effort to identify new drug candidates for lymphatic filariasis, we conducted a three-way transcriptomics/systems biology study of one of the causative agents of lymphatic filariasis, Brugia malayi , its Wolbachia endosymbiont w Bm, and its vector host Aedes aegypti at 16 distinct B. malayi life stages. B. malayi upregulates...

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PMID: 31796568
DOI: 10.1128/msystems.00596-19

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