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Article

Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients.

The Journal of infectious diseases - 16 Mar 2020

Douglas Cameron M, Barnard Richard, Holder Daniel, Leavitt Randi, Levitan Diane, Maguire Maureen, Nickle David, Teal Valerie, Wan Hong, van Alewijk Dirk C J G, van Doorn Leen-Jan, Chou Sunwen, Strizki Julie

Abstract excerpt

BACKGROUND: Letermovir (LET), a cytomegalovirus (CMV) deoxyribonucleic acid (DNA) terminase inhibitor, was recently approved for prophylaxis of CMV infection in adult CMV-seropositive recipients of allogeneic hematopoietic stem cell transplantation. Cytomegalovirus genotyping was performed to identify LET-resistance-associated variants (RAVs) among subjects in a Phase 3 trial. METHODS: The CMV UL56 and UL89...

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PMID: 31781762
DOI: 10.1093/infdis/jiz577
PMCID: PMC7075417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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