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Article

New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir.

Antimicrobial agents and chemotherapy - 1 Sept 2018

Chou Sunwen, Satterwhite L Elizabeth, Ercolani Ronald J

Abstract excerpt

Letermovir is a human cytomegalovirus (CMV) terminase inhibitor recently approved as prophylaxis in stem cell transplant recipients. In further studies of emerging drug resistance, a baseline laboratory CMV strain was serially propagated in cell culture under a combination of letermovir and ganciclovir. In eight experiments, UL56 terminase gene mutations were detected beginning at 10 passages and included novel...

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Identifiers

PMID: 29914965
DOI: 10.1128/AAC.00922-18
PMCID: PMC6125535

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New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir.PMID 29914965Read ↗

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