Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma

14 May 2019

Abstract excerpt

BACKGROUND: Glioblastoma is a disease with high heterogeneity that has long been difficult for doctors to identify and treat. ARHI is a remarkable tumor suppressor gene in human ovarian cancer and many other cancers. We found over-expression of ARHI can also inhibit cancer cell proliferation, decrease tumorigenicity, and induce autophagic cell death in human glioma and inhibition of the late stage of autophagy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cellular transport and secretion
Share to Genetic Syndromes and Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31088402
DOI: 10.1186/s12885-019-5643-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastomaPMID 31088402Read ↗

Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in GlioblastomaSemantic proximity Read ↗

Proapoptotic and proautophagy effect of H1- receptor antagonist desloratadine in human glioblastoma cell linesSemantic proximity Read ↗

Advanced Bioinformatics Analysis and Genetic Technologies for Targeting Autophagy in Glioblastoma MultiformeSemantic proximity Read ↗

Therapeutic Exploitation of Apoptosis and Autophagy for GlioblastomaSemantic proximity Read ↗

Investigating the Association between the Autophagy Markers LC3B, SQSTM1/p62, and DRAM and Autophagy-Related Genes in GliomaSemantic proximity Read ↗

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cellsSemantic proximity Read ↗

Combined EGFR and Autophagy Modulation Impairs Cell Migration and Enhances Radiosensitivity in Human Glioblastoma CellsSemantic proximity Read ↗

Autophagy-associated biomarkers ULK2, UVRAG, and miRNAs miR-21, miR-126, and miR-374: Prognostic significance in glioma patientsSemantic proximity Read ↗

The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent EffectsSemantic proximity Read ↗

GANT-61 Induces Autophagy and Apoptosis in Glioblastoma Cells despite their heterogeneitySemantic proximity Read ↗

ANTXR1 Facilitates Tumor Growth in Glioma via Deactivating MAPK Signaling PathwaySemantic proximity Read ↗

ERK inhibition in glioblastoma is associated with autophagy activation and tumorigenesis suppressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.