Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia

26 Jan 2016

Abstract excerpt

Mitochondrial autophagy (mitophagy) is a selective form of autophagy and a critical step in excluding mitochondria damaged by stress, including hypoxia. This study aimed to determine whether the integrity of mitophagy affected production of the mitochondrial reactive oxygen species (mtROS), hypoxia inducible factor (HIF)-1α expression and aggressive characteristics in GC cells under hypoxia. Three GC cell lines,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer, Hypoxia, and Metabolism
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26820502
DOI: 10.3892/ijo.2016.3359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxiaPMID 26820502Read ↗

Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulationSemantic proximity Read ↗

Hypoxia and Selective Autophagy in Cancer Development and TherapySemantic proximity Read ↗

Investigating the Association between the Autophagy Markers LC3B, SQSTM1/p62, and DRAM and Autophagy-Related Genes in GliomaSemantic proximity Read ↗

Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancerSemantic proximity Read ↗

Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted ParadoxSemantic proximity Read ↗

Emerging Role of Hypoxia-Inducible Factors (HIFs) in Modulating Autophagy: Perspectives on Cancer TherapySemantic proximity Read ↗

Autophagic tumor stroma: Mechanisms and roles in tumor growth and progressionSemantic proximity Read ↗

The role of autophagy in colorectal cancer: Impact on pathogenesis and implications in therapySemantic proximity Read ↗

p62 degradation by autophagy: Another way for cancer cells to survive under hypoxiaSemantic proximity Read ↗

Hypoxia-associated autophagy flux dysregulation in human cancersSemantic proximity Read ↗

Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic PotentialSemantic proximity Read ↗

The role of autophagy in hypoxia-induced radioresistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.