Article
Inactivation pattern of the fragile X in heterozygous carriers.
American journal of medical genetics - 1 Jan 2000
Fryns J P, Van den Berghe H
Abstract excerpt
In this report we present new data on BrdU-inactivation studies in lymphocytes of five heterozygotes. The present data confirm our previous findings that the prediction of the mental status of female heterozygote carriers cannot be based on the X-inactivation pattern. The general tendency to carry the fragile site on the active X is confirmed and the results of previous studies and hypotheses are reviewed.
Topics
- Adult
- Dosage Compensation, Genetic
- Female
- Fragile X Syndrome
- Heterozygote
- Humans
- Intelligence
- Lymphocytes
- Phenotype
- Sex Chromosome Aberrations