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Mitochondrial Damage Mediated by miR-1 Overexpression in Cancer Stem Cells

24 Oct 2019

Abstract excerpt

It is well known that cells rely on mitochondrial respiration for survival. However, the effect of microRNAs (miRNAs) on mitochondria of cells has not been extensively explored. Our results indicated that the overexpression of a miRNA (miR-1) could destroy mitochondria of cancer stem cells. miR-1 was downregulated in melanoma stem cells (MSCs) and breast cancer stem cells (BCSCs) compared with cancer non-stem...

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PMID: 31765945
DOI: 10.1016/j.omtn.2019.10.016

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