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Article

[Analysis of the possible mechanisms for the persistence of the vaccinal strain of the measles virus in a human cell culture].

Voprosy virusologii - 1 Jan 2000

Andzhaparidze O G, Bogomolova N N, Boriskin Iu S, Koptiaeva I B, Chaplygina N M

Abstract excerpt

The mechanisms (factors) of the measles virus vaccine L-16 strain persistence in HEp-2 cell culture were analysed. Among the known mechanisms, most likely is the reduction of the cell-destroying properties of the persisting virus due to mutations in nucleoprotein gene manifested by changes of the isoelectric point of NP protein and temperature sensitivity of its synthesis.

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Source

Identifiers

PMID: 3176432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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