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Article

HIV-1 genetic diversity to estimate time of infection and infer adherence to preexposure prophylaxis.

AIDS (London, England) - 1 Dec 2019

Council Olivia D, Ruone Susan, Mock Philip A, Khalil George, Martin Amy, Curlin Marcel E, McNicholl Janet M, Heneine Walid, Leelawiwat Wanna, Choopanya Kachit, Vanichseni Suphak, Cherdtrakulkiat Thitima, Anekvorapong Rapeepan, Martin Michael, García-Lerma José Gerardo

Abstract excerpt

OBJECTIVE: To estimate time of HIV infection in participants from the Bangkok Tenofovir Study (BTS) with daily oral tenofovir disoproxil fumarate (TDF) for preexposure prophylaxis (PrEP) and relate infection with adherence patterns. DESIGN: We used the diversity structure of the virus population at the first HIV RNA-positive sample to estimate the date of infection, and mapped these estimates to medication...

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Identifiers

PMID: 31764095
DOI: 10.1097/QAD.0000000000002390
PMCID: PMC11000142

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