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Article

Vertical selection for nuclear and mitochondrial genomes shapes gut microbiota and modifies risks for complex diseases.

Physiological genomics - 1 Jan 2020

Zhang Youjie, Kumarasamy Sivarajan, Mell Blair, Cheng Xi, Morgan Eric E, Britton Steven L, Vijay-Kumar Matam, Koch Lauren Gerard, Joe Bina

Abstract excerpt

Here we postulate that the heritability of complex disease traits previously ascribed solely to the inheritance of the nuclear and mitochondrial genomes is broadened to encompass a third component of the holobiome, the microbiome. To test this, we expanded on the selectively bred low capacity runner/high capacity runner (LCR/HCR) rat exercise model system into four distinct rat holobiont model frameworks...

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Identifiers

PMID: 31762410
DOI: 10.1152/physiolgenomics.00089.2019
PMCID: PMC8526334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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