Article
The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms.
BioMed research international - 1 Jan 2014
Garagnani Paolo, Pirazzini Chiara, Giuliani Cristina, Candela Marco, Brigidi Patrizia, Sevini Federica, Luiselli Donata, Bacalini Maria Giulia, Salvioli Stefano, Capri Miriam, Monti Daniela, Mari Daniela, Collino Sebastiano, Delledonne Massimo, Descombes Patrick, Franceschi Claudio
Abstract excerpt
Usually the genetics of human longevity is restricted to the nuclear genome (nDNA). However it is well known that the nDNA interacts with a physically and functionally separated genome, the mitochondrial DNA (mtDNA) that, even if limited in length and number of genes encoded, plays a major role in the ageing process. The complex interplay between nDNA/mtDNA and the environment is most likely involved in phenomena...
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