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Article

[Several hot issues in the detection of plasma EGFR mutations in advanced non-small-cell lung cancer patients].

Zhonghua yi xue za zhi - 19 Nov 2019

Chen Y Z, Xu G B, Guan S N, Jia S Q, Kang X Z, Zhao J, Wang G H, Ji J F

Abstract excerpt

表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor tyrosine kinase inhibitors, EGFR-TKIs）为EGFR敏感突变的晚期非小细胞肺癌（non-small-cell lung cancer，NSCLC）患者的一线治疗药物。首选组织用于EGFR基因突变检测，晚期NSCLC患者血浆EGFR基因突变与组织具有良好的一致性，是组织检测的补充。血浆中循环肿瘤DNA（circulating tumor DNA，ctDNA）含量低、片段短，易受血液中野生型DNA污染。血样收集、ctDNA提取、各个检测环节的质量控制和检测技术人员的规范培训均影响血浆EGFR基因突变检测结果的准确性。本文对晚期NSCLC患者血浆EGFR基因突变检测应该注意的问题进行概括。.

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Identifiers

PMID: 31752461
DOI: 10.3760/cma.j.issn.0376-2491.2019.43.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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