Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.

Abstract excerpt

The ability of Mycobacterium tuberculosis (Mtb) to persist in its host is central to the pathogenesis of tuberculosis, yet the underlying mechanisms remain incompletely defined. PerM, an integral membrane protein, is required for persistence of Mtb in mice. Here, we show that perM deletion caused a cell division defect specifically during the chronic phase of mouse infection, but did not affect Mtb's cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Cycle Proteins
• Share to Cell Division
• Share to Gene Expression Regulation, Bacterial