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Accelerated hippocampal biological aging in bipolar disorder

20 Nov 2019

Abstract excerpt

OBJECTIVES: Evidence suggests accelerated aging mechanisms in bipolar disorder (BD), including DNA methylation (DNAm) aging in blood. However, it is unknown whether such mechanisms are also evident in the brain, in particular in association with other biological clocks. To investigate this, we interrogated genome-wide DNAm in postmortem hippocampus from 32 BD-I patients and 32 non-psychiatric controls...

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PMID: 31746071
DOI: 10.1111/bdi.12876

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