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Article

Fetal cardiac rhabdomyomas treated with maternal sirolimus.

Prenatal diagnosis - 1 Feb 2020

Pluym Ilina D, Sklansky Mark, Wu Joyce Y, Afshar Yalda, Holliman Kerry, Devore Greggory R, Walden Ayanna, Platt Lawrence D, Krakow Deborah

Abstract excerpt

OBJECTIVE: To review the pathophysiology of rhabdomyomas and the emerging option of prenatal treatment of fetal cardiac rhabdomyomas. METHODS: We present a case of fetal rhabdomyomas causing significant hemodynamic compromise that received in utero treatment of maternal sirolimus. Genetic amniocentesis confirmed a TSC2 mutation. A treatment program was initiated with a 10-mg loading dose titrated to a goal...

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Identifiers

PMID: 31742705
DOI: 10.1002/pd.5613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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