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Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway

1 Nov 2019

Abstract excerpt

A major problem with chondrocytes derived in vitro from stem cells is undesired hypertrophic degeneration, to which articular chondrocytes (ACs) are resistant. As progenitors of all adult tissues, induced pluripotent stem cells (iPSCs) are in theory able to form stable articular cartilage. In vitro differentiation of iPSCs into chondrocytes with an AC-phenotype and resistance to hypertrophy has not been...

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PMID: 31737632
DOI: 10.3389/fcell.2019.00270

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