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Pathogenicity of Clinical OXA-48 Isolates and Impact of the OXA-48 IncL Plasmid on Virulence and Bacterial Fitness

1 Nov 2019

Abstract excerpt

OXA-48 is the most common carbapenemase in Germany and one of the most frequent carbapenemases worldwide. Several reports have associated blaOXA-48 with a virulent host phenotype. To challenge this hypothesis, 35 OXA-48-producing clinical isolates of Escherichia coli (n=15) and Klebsiella pneumoniae (n=20) were studied in vitro, in vivo and by whole-genome sequencing. Clinical isolates belonged to 7 different...

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Identifiers

PMID: 31736929
DOI: 10.3389/fmicb.2019.02509

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