Article
ZP1 mutations are associated with empty follicle syndrome: evidence for the existence of an intact oocyte and a zona pellucida in follicles up to the early antral stage. A case report.
Human reproduction (Oxford, England) - 1 Nov 2019
Dai Can, Chen Yongzhe, Hu Liang, Du Juan, Gong Fei, Dai Jing, Zhang Shuoping, Wang Mingyi, Chen Jing, Guo Jing, Zheng Wei, Lu Changfu, Wu Yueren, Lu Guangxiu, Lin Ge
Abstract excerpt
Empty follicle syndrome (EFS) is the complete failure to retrieve oocytes after ovarian stimulation. Although LHCGR and ZP3 were identified as causative genes, it is still unclear what happens to these patients' oocytes, and the pathogenesis of EFS remains obscure. Here, we identified six novel ZP1 mutations associated with EFS and female infertility that was inherited recessively in five unrelated families....
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