Article
Role of cilia in structural birth defects: insights from ciliopathy mutant mouse models.
Birth defects research. Part C, Embryo today : reviews - 1 Jun 2014
Rao Damerla Rama, Gabriel George C, Li You, Klena Nikolai T, Liu Xiaoqin, Chen Yu, Cui Cheng, Pazour Gregory J, Lo Cecilia W
Abstract excerpt
Structural birth defect (SBD) is a major cause of morbidity and mortality in the newborn period. Although the etiology of SBD is diverse, a wide spectrum of SBD associated with ciliopathies points to the cilium as having a central role in the pathogenesis of SBDs. Ciliopathies are human diseases...
Topics
- Animals
- Brain
- Cilia
- Congenital Abnormalities
- Disease Models, Animal
- Dyskinesias
- Heart Defects, Congenital
- High-Throughput Nucleotide Sequencing
- Mice
- Mutation
- Organelles
- Signal Transduction