Article
Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics.
PLoS biology - 1 Nov 2019
Hicks Allison L, Kissler Stephen M, Lipsitch Marc, Grad Yonatan H
Abstract excerpt
The sensitivity of genotype-based diagnostics that predict antimicrobial susceptibility is limited by the extent to which they detect genes and alleles that lead to resistance. As novel resistance variants are expected to emerge, such sensitivity is expected to decline unless the new variants are detected and incorporated into the diagnostic. Here, we present a mathematical framework to define how many diagnostic...
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