Article
Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity.
Nature biomedical engineering - 1 Dec 2019
Jundi Bakr, Ryu Hyunryul, Lee Do-Hyun, Abdulnour Raja-Elie E, Engstrom Braden D, Duvall Melody G, Higuera Angelica, Pinilla-Vera Mayra, Benson Maura E, Lee Jaemyon, Krishnamoorthy Nandini, Baron Rebecca M, Han Jongyoon, Voldman Joel, Levy Bruce D
Abstract excerpt
Dysregulated leukocyte responses underlie the pathobiology of sepsis, which is a leading cause of death. However, measures of leukocyte function are not routinely available in clinical care. Here we report the development and testing of an inertial microfluidic system for the label-free isolation and downstream functional assessment of leukocytes from 50 μl of peripheral blood. We used the system to assess...
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