Article
A functional polymorphism in the promoter of miR-17-92 cluster is associated with decreased risk of ischemic stroke.
BMC medical genomics - 8 Nov 2019
Huang Huatuo, Wei Guijiang, Wang Chunfang, Lu Yulan, Liu Chunhong, Wang Rong, Shi Xiang, Yang Jun, Wei Yesheng
Abstract excerpt
BACKGROUND: The microRNA-17-92 (miR-17-92) cluster is one of the most extensively studied miRNA clusters. Abnormal expression of the cluster has been found to play important role in different kinds of human diseases, including ischemic stroke (IS). The aim of our study was to investigate the association between three polymorphisms (rs1491034, rs9301654 and rs982873) in the promoter of the miR-17-92 cluster and...
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