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Article

The ACTIVE study protocol: apatinib or placebo plus gefitinib as first-line treatment for patients with EGFR-mutant advanced non-small cell lung cancer (CTONG1706).

Cancer communications (London, England) - 7 Nov 2019

Zhang Zhonghan, Luo Fan, Zhang Yang, Ma Yuxiang, Hong Shaodong, Yang Yunpeng, Fang Wenfeng, Huang Yan, Zhang Li, Zhao Hongyun

Abstract excerpt

BACKGROUND: Gefitinib, as the first epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) approved for the treatment of advanced non-small cell lung cancer (NSCLC), has been proved to significantly improve the progression-free survival (PFS) in the first-line setting but suffers from resistance 7-10 months after treatment initiation. Apatinib (YN968D1), a potent vascular endothelial growth factor...

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PMID: 31699150
DOI: 10.1186/s40880-019-0414-4
PMCID: PMC6839103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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